Wednesday, January 23, 2008

Advanced Pain Reliever Plus New Nano Technology

Do you want a Safe and Effective Pain Reliever that not only give fast and powerful pain relief but also new technology to deliver nutrients that the body needs to heal itself directly to the injured area?

Do you want a natural Homeopathic treatment that works fast?

Read on and Learn Why NeoFlexcin is Right For You?

Putting Reality of health and the Body in Proper Perspective:
Vitamins, Healing Oils, Herbs and More:
Conventional wisdom today regarding supplements dictates that all one needs to do is provide the “Body” with enough of the good: vitamins, botanicals, herbs, oils, and other supplements “The More the merrier”, will most certainly give the “Body” all it needs to treat itself?
Have you bought into this philosophy?
Ready, for an Eye Opener?
Most conventional medications treat symptoms without regard to healing or fixing the problem.
Most Vitamin purveyors and nutriceutical promoters, operate on the philosophy that The more one consumes either orally or topically (through the skin), the better it is for the “Body”. I bet you wish it was that simple. Many still operate under the illusion that it is that simple.
If things are the way they are portrayed above then someone, please tell us why oral supplementation is at most 3 to 5% effective. That’s right only 3 – 5% of all orally
Delivered supplements ever make it into the body. The next question should be,
What now? That is probably the same question that your body is asking! Just because a specific nutrient or supplement is available in your body does not mean
That it is bio-available or (usable). A perfect example is Calcium. Did you know that calcium in its natural state can not be absorbed? Puzzled? That’s right, in order for the body to assimilate calcium two other minerals have to be present magnesium and phosphorus, along with specific enzymes (substrates), normally produced by the body or absorbed from outside sources, act as the catalyst for this wonderful transformation process. We all need to realize is that without the catalyst there is little if any assimilation activity and these beneficial supplements are simply eliminated through the digestive system.

RAW Calcium BIO Available (Calcium) Chemicals required:
1. Phosphorus
2. Magnesium
3. Enzyme Substrates
4. Boron


In brief, the technologies utilized in all of Greystone’s products are state of the art methodologies producing effective results. By eliminating the Hepatic pathway, the net results are fewer materials used producing better, less expensive and quicker healing. Less material is possible because the area affected is the only area product is applied. Unlike the traditional oral pathway, which the product is evenly distributed though the body, Greystone’s allow only the area that needs the nutrients to receive the nutrients.
This is both cost effective and speeds the healing process by eliminating the traditional Hepatic pathway.

Drug delivery:
A tiny timely vehicle
from Nature Reviews Cancer

Jenny Bangham

The administration of chemotherapy together with anti-angiogenic drugs seems to be a particularly effective way of slowing tumor growth. However, this combination also poses some practical problems — cutting off the tumor blood supply makes it difficult to achieve a high drug concentration, and hypoxia can trigger the expression of chemotherapy-resistance genes. Now, a group led by Ram Sasisekharan has designed a sophisticated delivery system that gets around these complications — a 'nanocell' that localizes to tumors and then shuts down the tumor vasculature before delivering a cytotoxic agent to tumor cells.

Their nanocell consists of a phosopholipid envelope and, inside it, a nanoparticle made of a biodegradable polymer. The researchers incorporated an anti-angiogenic agent — in this case combretastatin — into the liposome, and attached the chemotherapeutic agent doxorubicin to the nanoparticle.

They found that combretastatin escapes rapidly from the lipid envelope, while the conjugated doxorubicin is freed more slowly, degrading into smaller, inactive fragments before breaking down further into free, active doxorubicin. These release kinetics correlate well with the effect of the nanocell combination on the tumor endothelium in vitro — the system caused the vasculature to collapse as early as 12 hours post-administration, and tumors to be completely ablated by 30 hours.

The authors tested the therapeutic efficacy of this system in vivo using mice with B16:F10 melanomas and mice with Lewis lung carcinoma. They compared the effects of sequential drug delivery using nanocells with several other treatments —one or both drugs delivered simultaneously in simple liposomes, nanocells containing doxorubicin alone or co-administration of doxorubicin-containing nanocells and combrestatin-containing liposomes. Animals treated with nanocells containing both drugs had a better tumor response than any of the other treatment groups. In fact, the increase in survival of mice given the drugs sequentially was about twice that of those given the drugs simultaneously.

Furthermore, the nanocells containing both drugs resulted in the lowest systemic toxicity of all of the treatments. This is probably because the cytotoxic agent is localized to the tumor so effectively — the researchers confirmed this by attaching the dye fluorescein to the nanocell and measuring concentration of the dye in tumors and highly vascular organs. They speculate that the nanocell might be retained preferentially in tumors because tumor vasculature is 'leakier' than normal vasculature, and allows tumor tissue to absorb large particles.

How does the temporal delivery system elicit such a good response? The authors found that the nanocells containing both drugs caused higher levels of apoptosis than the other treatments, as well as the lowest expression of hypoxia-inducible factor 1 (HIF1), which they attribute to the high concentration of doxorubicin inside the tumor.

So what next for this new system? The nanocells used in this study could be developed further by adding probes that target the tumor vasculature more specifically. The authors point out that temporal drug delivery could substantially improve the efficacy of existing drugs, thereby reducing the risk and time for developing new therapies.


ORIGINAL RESEARCH PAPER Sengupta, S. et al. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 436, 568–572 (2005)


Dr. Gary Canady


Dr. Bob Pettis